An unusual type of Breast Cancer...
Women's magazines and articles seldom explain about this quite common form of Breast Cancer. Please read further for information and details in regards to Paget's Disease, (information courtesy of Cancer BackUp).
Paget's disease of the breast
Paget’s disease of the breast is an eczema-like change in the skin of the nipple, and 9 out of 10 women who have this have an underlying breast cancer. The underlying breast cancer may be an invasive breast cancer or ductal carcinoma in situ (DCIS). In DCIS, the cancer cells are completely contained within the milk ducts.
Around half of the women who have Paget’s disease will have a breast lump that can be felt at the time it is diagnosed.
Paget’s disease occurs in about 1–2 out of every 100 women with breast cancer. It usually occurs in women in their 50s, but can occur at an earlier or later age. It can affect men but this is extremely rare. It usually first appears as a scaly, red rash affecting the nipple and sometimes the dark area of skin surrounding the nipple (the areola). The rash always affects the nipple first, and may then affect the areola. It does not go away and may become sore. The area may bleed slightly.
Causes of Paget's disease
The cause of Paget's disease is unknown, but certain women seem to be at a higher risk of developing breast cancer. This includes women who have never had children, or had them late in life, women who started their periods at a young age or who had a late menopause, and women who have a strong family history of breast cancer.
The first symptom is usually an eczema-like rash, as described earlier. The skin of the nipple and areola may be red and inflamed. There may also be crusting, bleeding and ulceration. Some women have an itching or burning sensation. Fluid (discharge) may leak from the abnormal area of cells. The nipple may turn inwards (be inverted). There may or may not be a lump in the breast.
Paget’s disease can be confused with other skin conditions such as eczema, dermatitis or psoriasis, as they can look very similar. This can make Paget’s disease difficult to diagnose.
Paget’s disease usually first affects the nipple, and then the surrounding tissue. Other skin conditions usually affect the areola (the dark area of skin around the nipple) first, and then spread into the nipple.
Several tests may be carried out to diagnose Paget’s disease of the breast. They may include the following:
Mammogram (breast x-ray) Mammograms may be used to look for changes in the affected breast, and to check the other breast.
Ultrasound scan A gel is spread on the breast and a small device, which emits sound waves, is rubbed over the area. The echoes are converted into a picture of the breast tissue by a computer. This test is painless and takes just a few minutes.
Biopsy This is the main test for cancer cells below the skin surface. A small sample of skin and underlying breast tissue is taken and sent to the laboratory to be examined under a microscope. A local anaesthetic is usually given before before the biopsy is carried out, to numb the area. The biopsy may be taken at the same time as an ultrasound, to ensure that it is taken from the abnormal area.
Imprint or scrape cytology Cells from the affected area can be scraped, or pressed, onto a glass slide to be examined under a microscope.








